Non‐genetic forms of antimicrobial (drug) resistance can result from cell‐to‐cell variability that is not encoded in the genetic material. Data from recent studies also suggest that non‐genetic mechanisms can facilitate the development of genetic drug resistance. We speculate on how the interplay between non‐genetic and genetic mechanisms may affect microbial adaptation and evolution during drug treatment. We argue that cellular heterogeneity arising from fluctuations in gene expression, epigenetic modifications, as well as genetic changes contribute to drug resistance at different timescales, (...) and that the interplay between these mechanisms enhance pathogen resistance. Accordingly, developing a better understanding of the role of non‐genetic mechanisms in drug resistance and how they interact with genetic mechanisms will enhance our ability to combat antimicrobial resistance. Also see the video abstract here: https://youtu.be/aefGpdh-bgU. (shrink)

In this paper, I argue that explanations just ARE those sorts of things that, under the right circumstances and in the right sort of way, bring about understanding. This raises the question of why such a seemingly simple account of explanation, if correct, would not have been identified and agreed upon decades ago. The answer is that only recently has it been made possible to analyze explanation in terms of understanding without the risk of collapsing both to merely phenomenological states. (...) For the most part, theories of explanation were for 50 years held hostage to the historical accident that they far outstripped in sophistication corresponding accounts of understanding. (shrink)

As a strategy for exploring the relationship between understanding and knowledge, we consider whether epistemic luck – which is typically thought to undermine knowledge – undermines understanding. Questions about the etiology of understanding have also been at the heart of recent theoretical debates within epistemology. Kvanvig (2003) put forward the argument that there could be lucky understanding and produced an example that he deemed persuasive. Grimm (2006) responded with a case that, he argued, demonstrated that there could not be lucky (...) understanding. In this paper, we empirically examine how participants' patterns of understanding attributions line up with the predictions of Kvanvig and Grimm. We argue that the data challenge Kvanvig's position. People do not differentiate between knowing-why and understanding-why on the basis of proper etiology: attributions of knowledge and understanding involve comparable (and minimal) roles for epistemic luck. We thus posit that folk knowledge and understanding are etiologically symmetrical. (shrink)

This paper focuses on two questions: Is understanding intimately bound up with accurately representing the world? Is understanding intimately bound up with downstream abilities? We will argue that the answer to both these questions is “yes”, and for the same reason-both accuracy and ability are important elements of orthogonal evaluative criteria along which understanding can be assessed. More precisely, we will argue that representational-accuracy and intelligibility are good-making features of a state of understanding. Interestingly, both evaluative claims have been defended (...) by philosophers in the literature on understanding as the criterion of evaluation. We argue that proponents of both approaches have important insights and that, drawing on both their own observations and a few novel arguments, we can construct a more complete picture of understanding evaluation. We thus posit the theory of there being Multiple Understanding Dimensions. The main thing to note about our dualism regarding the evaluative criteria of understanding is that it accounts for the intuitions about cases underlying both previously held positions. (shrink)

The view that special science properties are multiply realizable has been attacked in recent years by Shapiro, Bechtel and Mundale, Polger, and others. Focusing on psychological and neuroscientific properties, I argue that these attacks are unsuccessful. By drawing on interspecies physiological comparisons I show that diverse physical mechanisms can converge on common functional properties at multiple levels. This is illustrated with examples from the psychophysics and neuroscience of early vision. This convergence is compatible with the existence of general constraints on (...) the evolution of cognitive systems, and does not involve any ad hoc typing of coarse-grained higher level properties. The mechanisms that realize these common higher level properties are really distinct by the criteria laid down by critics of multiple readability. Finally, I present an account of how such functional properties might constitute special science kinds by playing a central explanatory role in a range of cognitive models. Behavioral science kinds in particular are the functionally defined constituents picked out by our most successful models of the multilevel systems and mechanisms that explain cognitive capacities. (shrink)

Four experiments investigate the folk concept of “understanding,” in particular when and why it is deployed differently from the concept of knowledge. We argue for the positions that people have higher demands with respect to explanatory depth when it comes to attributing understanding, and that this is true, in part, because understanding attributions play a functional role in identifying experts who should be heeded with respect to the general field in question. These claims are supported by our findings that people (...) differentially withhold attributions of understanding when the object of attribution has minimal explanatory information. We also show that this tendency significantly correlates with people’s willingness to defer to others as potential experts. This work bears on a pressing issue in epistemology concerning the place and value of understanding. Our results also provide reason against positing a simple equation of knowledge and understanding. We contend that, because deference plays a crucial role in many aspects of everyday reasoning, the fact that we use understanding attributions to demarcate experts reveals a potential mechanism for achieving our epistemic aims in many domains. (shrink)

Claims pertaining to understanding are made in a variety of contexts and ways. As a result, few in the philosophical literature have made an attempt to precisely characterize the state that is y understanding x. This paper builds an account that does just that. The account is motivated by two main observations. First, understanding x is somehow related to being able to manipulate x. Second, understanding is a mental phenomenon, and so what manipulations are required to be an understander must (...) only be mental manipulations. Combining these two insights, the paper builds an account (URM) of understanding as a certain representational capacity—specifically, understanding x involves possessing a representation of x that could be manipulated in useful ways. By tying understanding to representation, the account correctly identifies that understanding is a fundamentally cognitive achievement. However, by also demanding that which representations count as understanding-conferring be determined by their practical effects, URM captures the insight that understanding is vitally connected to practice. URM is fully general, and can apply equally well to understanding states of affairs, understanding events, and even understanding people and works of art. The ultimate test of URM is its applicability in actual scientific and philosophical discourse. To that end the paper discusses the importance of understanding in the philosophy of science, psychology, and computer science. (shrink)

Employs the political philosophy of John Rawls to address controversies involving politics and religion.

Our goal in this paper is to experimentally investigate whether folk conceptions of explanation are psychologistic. In particular, are people more likely to classify speech acts as explanations when they cause understanding in their recipient? The empirical evidence that we present suggests this is so. Using the side-effect effect as a marker of mental state ascriptions, we argue that lay judgments of explanatory status are mediated by judgments of a speaker’s and/or audience’s mental states. First, we show that attributions of (...) both understanding and explanation exhibit a side-effect effect. Next, we show that when the speaker’s and audience’s level of understanding is stipulated, the explanation side-effect effect goes away entirely. These results not only extend the side-effect effect to attributions of understanding, they also suggest that attributions of explanation exhibit a side-effect effect because they depend upon attributions of understanding, supporting the idea that folk conceptions of explanation are psychologistic. (shrink)

In recent years, the ontological argument and theistic metaphysics have been criticised by philosophers working in both the analytic and continental traditions. Responses to these criticisms have primarily come from philosophers who make use of the traditional, and problematic, concept of God. In this volume, Daniel A. Dombrowski defends the ontological argument against its contemporary critics, but he does so by using a neoclassical or process concept of God, thereby strengthening the case for a contemporary theistic metaphysics. Relying on (...) the thought of Charles Hartshorne, he builds on Hartshorne's crucial distinction between divine existence and divine actuality, which enables neoclassical defenders of the ontological argument to avoid the familiar criticism that the argument moves illegitimately from an abstract concept to concrete reality. His argument, thus, avoids the problems inherent in the traditional concept of God as static. (shrink)

The rise of China, along with problems of governance in democratic countries, has reinvigorated the theory of political meritocracy. But what is the theory of political meritocracy and how can it set standards for evaluating political progress? To help answer these questions, this volume gathers a series of commissioned research papers from an interdisciplinary group of leading philosophers, historians and social scientists. The result is the first book in decades to examine the rise of political meritocracy and what it will (...) mean for political developments in China and the rest of the world. Despite its limitations, meritocracy has contributed much to human flourishing in East Asia and beyond and will continue to do so in the future. This book is essential reading for those who wish to further the debate and perhaps even help to implement desirable forms of political change. (shrink)

What is understanding? My goal in this paper is to lay out a new approach to this question and clarify how that approach deals with certain issues. The claim is that understanding is a matter of compressing information about the understood so that it can be mentally useful. On this account, understanding amounts to having a representational kernel and the ability to use it to generate the information one needs regarding the target phenomenon. I argue that this ambitious new account (...) can accommodate much of the data that has motivated theories of understanding in philosophy of science, and can also be generally applicable in epistemology and daily life as well. (shrink)

While considered by many as one of the greatest philosophers of religion and metaphysicians of the 20th century, Charles Hartshorne’s contributions to the study of aesthetics are perhaps the most neglected aspect of his extensive and highly nuanced thought. DIVINE BEAUTY offers the first detailed explication of Hartshorne’s aesthetic theory and its place within his theocentric philosophy.

It has often been noticed that Plato's metaphysical view of being is dipolar. The purpose of the present article is to detail what it means to say that being is dipolar in Plato. Further, I will explore the extent to which dipolarity in Whitehead is indebted to Plato and the extent to which Whitehead's dipolarity is different from Plato's. In this regard I will concentrate on Whitehead's recently published Harvard Lectures.

Daniel Heller contends that public education is in a downward spiral because we have failed to notice the erosion of the basic curricular dimensions which support the preparation of students as active participants in our ever-changing world. While many books explain procedural knowledge such as how to differentiate instruction, how to create standards-based curriculum, or how to write a constructivist lesson—Curriculum on the Edge of Survival discusses the "what" and "why" rather than the how. What is the purpose of (...) schools in a free, democratic society, and why is the answer to that question crucial in deciding the most fundamental questions about curriculum? (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Reinhold Niebuhr’s Paradox: Paralysis, Violence, and Pragmatism by Daniel Malotky, and: Moral Man and Immoral Society: A Study in Ethics and Politics by Reinhold Niebuhr, and: An Interpretation of Christian Ethics by Reinhold NiebuhrDaniel A. MorrisReinhold Niebuhr’s Paradox: Paralysis, Violence, and Pragmatism By Daniel Malotky LANHAM, MD: LEXINGTON BOOKS, 2011. 124 PP. $52.50Moral Man and Immoral Society: A Study in Ethics and Politics By Reinhold Niebuhr, (...) with a foreword by Cornel West LOUISVILLE: WESTMINSTER JOHN KNOX PRESS, 2013 (ORIG. PUB. 1932) 320 PP. $30.00An Interpretation of Christian Ethics By Reinhold Niebuhr, with an introduction by Edmund N. Santurri LOUISVILLE: WESTMINSTER JOHN KNOX PRESS, 2013 (ORIG. PUB. 1935). 278 PP. $30.00Have we been passing through a revival of interest in Reinhold Niebuhr since Barack Obama reported to David Brooks in 2007 that Niebuhr “is one of my favorite philosophers”? Or did Niebuhr’s work never go out of style in the first place? Whether current publishing trends reflect a revival or the norm, these three books highlight Niebuhr’s enduring relevance. They also show that Niebuhr’s lasting influence has not made him immune to criticism. Perhaps most important, they demonstrate that his insights can speak productively to contemporary issues whose urgency he may not have recognized.The new editions of An Interpretation of Christian Ethics and Moral Man and Immoral Society from Westminster John Knox Press contain welcome contributions to scholarship on Niebuhr. Originally delivered as the 1934 Rauschenbusch Memorial Lectures at Colgate-Rochester Divinity School, Interpretation was first published in 1935. A 1956 edition added a preface in which Niebuhr summarizes the text’s central claims and expresses a desire to revise many of his arguments. The new edition of Interpretation retains Niebuhr’s 1956 preface, and adds an introduction by Edmund N. Santurri, which precedes the preface. In his introduction, Santurri claims that this text “may well be Reinhold Niebuhr’s most important work in theological ethics,” despite Niebuhr’s confession of embarrassment in the preface (ix; italics in the original). For Santurri, Interpretation provides much-needed theological background for the ethical and political claims in Moral Man and Immoral Society. Moreover, Santurri holds [End Page 207] that the important features of Niebuhr’s mature theological anthropology were present in nascent form in Interpretation. Thus, the text’s lasting influence is clear: To understand the ethical and political insights in the other works in Niebuhr’s corpus, one must understand the developing theological anthropology presented in Interpretation.Having made this case for the text’s importance, Santurri devotes the bulk of his introduction to reviewing four arguments that critics level against Niebuhr. They are, briefly, feminist arguments against the portrayal of agape as self-sacrifice, just war arguments against the claim that the Gospels prescribe nonresistance, Anabaptist arguments against Constantinian Christianity (which Santurri traces to the differing soteriologies of Yoder and Niebuhr), and theological arguments that Niebuhr’s doctrine of God is incoherent. Santurri concludes that the first three critiques of Niebuhr ultimately fail for a variety of reasons, but suggests the fourth critique is valid. Even if he dismisses the first three arguments too easily, this is a clear, responsible, and thorough review of critical receptions of Niebuhr. The footnotes point the way to excellent resources, orienting readers to four important conversations in short order. Scholars and graduate students who study Niebuhr will benefit from this introduction, as will readers who desire a concise guide to critical receptions of Niebuhr’s work.Originally published in 1932, Moral Man and Immoral Society is more recognizable than Interpretation as one of Niebuhr’s landmark works. Perhaps for this reason, Westminster John Knox Press produced another edition of this text in 2002. That edition included an introduction by Langdon B. Gilkey, which appraised the influence of Moral Man in part by describing the fresh perspective it brought to American theological ethics in the early twentieth century. The 2013 edition of Moral Man retains Gilkey’s introduction (as well as a 1960 preface by Niebuhr), which is preceded by Cornel West’s new foreword to the book. In his brief foreword, West claims that this text “is not only... (shrink)

In this essay, I explain why the traditional liberal consensus is needed now as much as it ever was.

Is liberal democracy appropriate for East Asia? In this provocative book, Daniel Bell argues for morally legitimate alternatives to Western-style liberal democracy in the region. Beyond Liberal Democracy, which continues the author's influential earlier work, is divided into three parts that correspond to the three main hallmarks of liberal democracy--human rights, democracy, and capitalism. These features have been modified substantially during their transmission to East Asian societies that have been shaped by nonliberal practices and values. Bell points to the (...) dangers of implementing Western-style models and proposes alternative justifications and practices that may be more appropriate for East Asian societies. If human rights, democracy, and capitalism are to take root and produce beneficial outcomes in East Asia, Bell argues, they must be adjusted to contemporary East Asian political and economic realities and to the values of nonliberal East Asian political traditions such as Confucianism and Legalism. Local knowledge is therefore essential for realistic and morally informed contributions to debates on political reform in the region, as well as for mutual learning and enrichment of political theories. Beyond Liberal Democracy is indispensable reading for students and scholars of political theory, Asian studies, and human rights, as well as anyone concerned about China's political and economic future and how Western governments and organizations should engage with China. (shrink)

In this essay I argue that Reinhold Niebuhr's ethics of self-restraint, though promising, is based on an incomplete and imprecise moral psychology. Although Niebuhr claims that reason cannot provide a sufficient grounding to motivate self-restraint, he does not disclose which human capacity might serve this purpose. I suggest that we can address this oversight by strengthening Niebuhr's tentative embrace of David Hume, and by developing a concept of the emotions in order to explain how human beings can cultivate a stable (...) inclination to self-restraint. This project is informed by and in the service of feminist critiques of Niebuhr and social concerns. (shrink)

Regardless of the inconsistencies between Plato and his inheritors, the late neo-Platonist Proclus offers poignant answers to several contemporary debatesimbedded in Socratic scholarship. In the following, we will concentrate on Proclus’s interpretation of the Socratic elenchos and the provocative concept of double ignorance by clarifying their appearance in The Commentary on Plato’s Parmenides and The Commentary on the Alcibiades I. In this endeavor we shall unpack how Proclus characterizes the elenchos as an authentic dialectic purifying its recipients from an evil (...) caused by the conceit to knowledge, a condition which unfortunately almost all men suffer and require treatment. (shrink)

In this article I defend the claim that nonhuman animals can be persons. In this regard I rely on the thought of neoclassical or process theists like Alfred North Whitehead and Charles Hartshorne. Their moderate stance regarding personhood is in contrast to the influential classical theistic view, which denies personhood status to nonhuman animals.

For much of the twentieth century, Confucianism was condemned by Westerners and East Asians alike as antithetical to modernity. Internationally renowned philosophers, historians, and social scientists argue otherwise in Confucian Political Ethics. They show how classical Confucian theory--with its emphasis on family ties, self-improvement, education, and the social good--is highly relevant to the most pressing dilemmas confronting us today. Drawing upon in-depth, cross-cultural dialogues, the contributors delve into the relationship of Confucian political ethics to contemporary social issues, exploring Confucian perspectives (...) on civil society, government, territorial boundaries and boundaries of the human body and body politic, and ethical pluralism. They examine how Confucianism, often dismissed as backwardly patriarchal, can in fact find common ground with a range of contemporary feminist values and need not hinder gender equality. And they show how Confucian theories about war and peace were formulated in a context not so different from today's international system, and how they can help us achieve a more peaceful global community. This thought-provoking volume affirms the enduring relevance of Confucian moral and political thinking, and will stimulate important debate among policymakers, researchers, and students of politics, philosophy, applied ethics, and East Asian studies. The contributors are Daniel A. Bell, Joseph Chan, Sin Yee Chan, Chenyang Li, Richard Madsen, Ni Lexiong, Peter Nosco, Michael Nylan, Henry Rosemont, Jr., and Lee H. Yearley. (shrink)

In this response, I do four things. First, I defend the claim that the action compatibility effect does not distinguish between embodied and traditional accounts of language comprehension. Second, I present neuroimaging and neuropsychological results that seem to support the traditional account. Third, I argue that metaphorical language poses no special challenge to the arguments I gave against embodied theories of comprehension. Fourth, I lay out the architecture of language I advocate and suggest the sorts of data that would decide (...) between traditional and embodied accounts.Keywords: Language; Comprehension; Perception; Action; Embodied cognition; Representation. (shrink)

This paper has both theoretical and practical ambitions. The theoretical ambitions are to explore what would constitute both effective and ethical treatment of Autism Spectrum Disorder.1 However, the practical ambition is perhaps more important: we argue that a dominant form of Applied Behavior Analysis, which is widely taken to be far-and-away the best “treatment”2 for ASD, manifests systematic violations of the fundamental tenets of bioethics. Moreover, the supposed benefits of the treatment not only fail to mitigate these violations, but they (...) often exacerbate them. Warnings of the perils of ABA are not original to us—autism advocates have been ringing this... (shrink)

The ancient background -- Weiss and the pursuit of bodily excellence -- Huizinga and the homo ludens hypothesis -- Feezell, moderation, and irony -- The process of becoming virtuous.

Let me first express my gratitude for the three detailed and informative critiques of my book The China Model. These critiques are themselves models of Confucian civility, even as they express sharp areas of disagreement. There does seem to be agreement that the ideal of a Confucian-inspired democratic meritocracy is a worthwhile political project, particularly in the Chinese political context, but Huang, Li, and Wang question my book's arguments in defense of this ideal. There are three kinds of critiques: the (...) need to take Confucianism more seriously, the need to take democracy more seriously, and the need to take political meritocracy more seriously. Let me try to respond to each critique in turn.Yong... (shrink)

In this paper, I explore the possibility that the point Kripke (1982) made about understanding meaning also applies to understanding social interaction. This understanding involves extending what one has learned from a finite number of past observations to provide normative guidance for an indefinitely complicated future. Kripke argues (to my mind correctly) that what one should do in the future is inevitably underdetermined by the infinite possible interpretations of the past. Moreover, no matter how much one attempts to make the (...) rules explicit, they will always be underspecified. I then explore the speculative hypothesis that having different tacit dispositions made manifest in one’s understanding of the rules of social engagement would look remarkably similar to tendencies exhibited by many autistic individuals. The analogy will say something substantive about how neurotypicals (and other autists) should treat the behavior of autistic individuals—if we are not even doing anything incorrect, then society should not be criticizing our means of engagement. (shrink)

Elizabeth Anderson claims that the argument from marginal cases is 'the central argument' behind the claim that nonhuman animals have rights. But she thinks, along with Cora Diamond, that the argument is 'obtuse'. Two different meanings could be intended here: that the argument from marginal cases is too blunt or dull to dissect the reasons why it makes sense to say that nonhuman animals have rights or that the argument from marginal cases is insensitive regarding nonrational human beings. The purpose (...) of the present article is to argue that, despite Anderson's and Diamond's nuanced and perceptive treatments of the argument from marginal cases, this argument is not obtuse in either sense of the term. (shrink)

Examines the concept of God which emerges from the writings of Nikos Kazantzakis and argues that he was a process theist.

In the spirit of Pierre Hadot’s analysis of the value of the present moment in Hellenistic philosophies on happiness, the following argues that the Neoplatonic tradition heralded a similar view about the soul’s well-being. Primarily, the value of the present moment in Plotinus focuses on his arguments regarding the immortal soul’s desire for eternity that is lived in the ‘actuality of life’ right now. In contrast, the following analyzes the later Platonists and argues that Proclus offers a more practical and (...) thick understanding of human happiness in relation to the present. Overall, for Proclus the good is revealed in the connective nature of the present moment, a good discovered in the soul’s temporal activities. (shrink)